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Lipoic Acid

The Bottom Line on Antioxidant Acitivity

  • Lipoic acid is known as a powerful and versatile antioxidant.

  • The "lipoic acid" in common supplements is a 50/50 mixture of two different "lipoic acid" molecules: the natural R(+)-lipoic acid, and the unnatural S(-)-form. This mixture is called the "racemate."

  • R(+)-lipoic acid is more easily absorbed and taken into the cells than S(-)-lipoic acid.

  • Both forms of lipoic acid can be made more powerful by "charging" them up into their DHLA form. R(+)-lipoic acid is upgraded much more rapidly than S(-)-lipoic acid.

  • Many studies have found that R(+)-lipoic acid provides much more effective protection than S(-)-lipoic acid or the racemate. In some cases, the S(-)-lipoic acid actually counteracts the effects of R(+)-lipoic acid.

  • Common "lipoic acid" supplements are thus like a house at war with itself. The S(-)-form should be removed from supplements in favor of pure R(+)-lipoic acid.


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Please consult with a health care professional before starting any supplementation program. The information contained on this site is general in nature and Company does not take any responsibility for any errors that may appear. Company has made every attempt to make the information as accurate as possible. However, Company does not warrant its accuracy. Please note that the statements on this web site have not been evaluated by the FDA.