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Supplement Facts
Serving Size: 2 tablets
Servings Per Container: 30

Per Serving
% Daily Value
Wheat amylase inhibitor 20 mg *
Banaba leaf extract (Lagerstroemia speciosa) (1 % corosolic acid) 32 mg *
Triple CTM Proprietary Carb Control Blend: Green tea leaf extract(180 mg epigallocatechin gallate and 100 mg caffeine), Phase 2®** brand bean extract (Phaseolus vulgaris) Starch Neutralizer ** and Vanadium (as vanadyl sulfate) 1700 mg *
*Daily Value Not Established

Other ingredients: dicalcium phosphate, microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate, silica and pharmaceutical glaze

A detailed explanation of each of the key ingredients *

Phase 2®** TM brand bean extract (Phaseolus vulgaris) starch neutralizer is made from white kidney bean extract, and is a carbohydrate neutralizer.

The protein from the bean has been clinically proven to bind to an enzyme called alpha amylase, which inhibits, and therefore prevents, the enzyme from converting starch into sugar and then to stored fat. Phase 2®** alpha amylase inhibitors have been shown to significantly reduce the absorption of starch in a human pilot trial. Another pilot clinical study using Phase 2®** reveals an average reduction of 66% in absorption of starch calories in a human trial.

Phase 2®** has also been shown to reduce weight in two separate human clinical trials. Phase 2®** has also been shown to be safe in both chronic and acute LD 50 toxicity studies.

Wheat Amylase Inhibitor — This newer, cutting-edge, natural, material is similar to Phase 2®** and has been shown to further "neutralize" and inhibit the digestive enzyme alpha-amylase before it can convert starch into glucose (and then fat).

Essentially, it allows most dietary carbohydrates to pass through the system undigested and with less caloric intake. In 1995 the Mayo Clinic published a paper reporting that wheat amylase inhibitor has significantly higher activity against human pancreatic amylase then bean amylase inhibitor.

Wheat amylase inhibitor was also effective against human salivary amylase while bean amylase inhibitor was not. This is important because salivary digests a portion of ingested starch in the stomach before it enters the intestines to be converted to sugar. The protein from the wheat amylase has also been clinically proven to bind to an enzyme called alpha amylase, which inhibits and therefore prevents the enzyme from converting starch into sugar and then stored fat. (See *W-1 for References)

Banaba Leaf Extract — Is a medicinal plant that grows in India, Southeast Asia and the Philippines. Traditional uses from the leaves are as a treatment for diabetes and hyperglycemia.

The hypoglycemic (blood sugar lowering) effect of banaba leaf extract is similar to that of insulin - which induces glucose transport from the blood into body cells. The active constituent in banaba leaf extract is a particularly active glucose transport enhancer, which has been shown to allow glucose into the body cells without insulin.

In the cells, glucose can be burned for energy rather than stored as body fat. Banaba leaf extract can also help balance blood sugar levels to reduce cravings for carbohydrates and sweets.

Benefits can include:

  • Balances blood sugar
  • Promotes healthy insulin levels
  • Controls appetite and food craving (especially carbohydrate cravings) and helps promote weight loss

Banaba leaf extract contains a triterpenoid compound known as corosolic acid - which has actions in stimulating glucose transport into cells. As such, banaba leaf extract plays a role in regulating levels of blood sugar and insulin in the blood. For some people, fluctuations in blood sugar and insulin are related to appetite, hunger and various food cravings - particularly craving for carbohydrates such as bread and sweets.

By keeping blood sugar and insulin levels in check, banaba leaf extract can be an effective supplement for promoting weight loss in certain individuals. The blood sugar regulating properties of banaba leaf extract have been demonstrated in cell culture, animal and human studies. In isolated cells, the active ingredient in banaba leaf extract, corosolic acid, is known to stimulate glucose uptake.

In humans with type II diabetes, banaba extract, at a dose of 16-48mg per day for 4-8 weeks, has been shown to be effective in reducing blood sugar levels (5%-30% reduction) and maintaining tighter control of blood sugar fluctuations.

An interesting "side-effect" of tighter control of blood sugar and insulin levels is a significant tendency of banaba leaf extract to promote weight loss (an average of 2-4 lbs. per month) - without significant dietary alterations. It is likely that modulation of glucose and insulin levels reduces total caloric intake somewhat and encourages moderate weight loss. (See *B -1 for References)

Green Tea Leaf Extract — Studies show that green tea extract can increase the body's metabolism to burn more fat and calories. Because it contains a moderate amount of caffeine, it can also increase energy levels and help control appetite.

Green tea extract rich in polyphenols (epigallocatechin gallate, or EGCG) may support a weight-loss program by increasing energy expenditure or by inhibiting the digestion of fat in the intestine.(158 159) Healthy young men who took two green tea capsules (containing a total of 50 mg of caffeine and 90 mg of EGCG) three times a day had a significantly greater energy expenditure and fat oxidation than those who took caffeine alone or placebo.(160)

In a preliminary study of moderately obese individuals, administration of a specific green tea extract (AR25) resulted in a 4.6% reduction in average body weight after 12 weeks.(161)

The amount of green tea extract used in this study supplied daily 270 mg of EGCG and 150 mg of caffeine. While caffeine is known to stimulate metabolism, it appears that other substances besides caffeine were responsible for at least part of the weight loss. (See *G -1 for References)

Vanadium— Is a trace mineral that has been shown to be helpful for regulating blood sugar and insulin utilization and to help metabolize glucose levels. Vanadium has positive effects on helping to normalize blood sugar for both hypoglycemia (low blood sugar) and diabetes (high blood sugar).

Triple CTM — Is our proprietary synergistic carb control blend of Phase 2®** brand bean extract (Phaseolus vulgaris) starch neutralizer**, Green Tea Leaf Extract and Vanadium.

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Wheat Amylase Inhibitor
(*W-1) Wheat Amylase Inhibitor References

  1. Marshall JJ, Lauda CM. Purification and properties of phaseolamin, an inhibitor of alpha-amylase, from the kidney bean, Phaseolus vulgaris. J Biol Chem 1975;250:8030-7.

  2. Choudhury A, Maeda K, Murayama R, DiMagno EP. Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones. Gastroenterology 1996;111:1313-20.

  3. Bo-Linn GW, Santa Ana CA, Morawski SG, Fordtran JS. Starch blockers-their effect on calorie absorption from a high-starch meal. N Engl J Med 1982;307:1413-6.

  4. Hollenbeck CB, Coulston AM, Quan R, et al. Effects of a commercial starch blocker preparation on carbohydrate digestion and absorption: in vivo and in vitro studies. Am J Clin Nutr 1983;38:498-503.

  5. Garrow JS, Scott PF, Heels S, et al. A study of 'starch blockers' in man using 13C-enriched starch as a tracer. Hum Nutr Clin Nutr 1983;37:301-5.

  6. Carlson GL, Li BU, Bass P, Olsen WA. A bean alpha-amylase inhibitor formulation (starch blocker) is ineffective in man. Science 1983;219:393-5.

  7. Brugge WR, Rosenfeld MS. Impairment of starch absorption by a potent amylase inhibitor. Am J Gastroenterol 1987;82:718-22.

  8. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

  9. Layer P, Carlson GL, DiMagno EP. Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans. Gastroenterology 1985;88:1895-902.

  10. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

  11. Boivin M, Flourie B, Rizza RA, et al. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology 1988;94:387-94.

  12. Lankisch M, Layer P, Rizza RA, DiMagno EP. Acute postprandial gastrointestinal and metabolic effects of wheat amylase inhibitor (WAI) in normal, obese, and diabetic humans. Pancreas 1998;17:176-81.

  13. Holt PR, Thea D, Yang MY, Kotler DP. Intestinal and metabolic responses to an alpha-glucosidase inhibitor in normal volunteers. Metabolism 1988;37:1163-70.

  14. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55. 15. Boivin M, Flourie B, Rizza RA, et al. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology 1988;94:387-94.

Banaba Leaf Extract (*B-1) Banaba Leaf Extract References

  1. Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem. 1996 Feb;60(2):204-8.

  2. Murakami C, Myoga K, Kasai R, Ohtani K, Kurokawa T, Ishibashi S, Dayrit F, Padolina WG, Yamasaki K. Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells. Chem Pharm Bull (Tokyo). 1993 Dec;41(12):2129-31.

  3. Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo). 1999 Dec;45(6):791-5.

Green Tea Leaf Extract (*G -1) References

  1. Dulloo AG, Seydoux J, Girardier L, et al. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord 2000;24:252-8.
  2. Juhel C, Armand M, Pafumi Y, et al. Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. J Nutr Biochem 2000;11:45-51.
  3. Dulloo AG, Duret C, Rohrer D, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999;70:1040-5.
  4. Chantre P, Lairon D. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 2002;9:3-8
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